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Episode 34 Cannabis & Adaptation

The Ultimate Bio-Hack

Forget nootropics and cold plunges. The most powerful bio-hack has been illegal for 80 years. How cannabis enhances neuroplasticity and adaptation.

By Justin Hartfield 4:20 Cannabis & Adaptation Updated December 22, 2025
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Justin Hartfield

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Justin Hartfield

Founder of Weedmaps, student of Dr. Bob Melamede, and explorer of far-from-equilibrium systems. Connecting thermodynamics, consciousness, and human potential.

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The Ultimate Bio-Hack

You’ve probably heard it all. The endless chatter about “bio-hacking” your way to a better life. Cold plunges that shock your system into submission. Nootropics that promise laser-focus and a brain like a supercomputer. Intermittent fasting that turns your body into a fat-burning machine. And sure, some of it works. For a while. But you’re missing the biggest damn piece of the puzzle. The one that’s been staring us in the face for centuries, hidden in plain sight, and demonized for the better part of a century.

I’m talking about cannabis.

Living on the edge of chaos means embracing experiences that challenge our preconceived notions and expand our understanding of reality. I learned this firsthand when I encountered a group of people who were using cannabis—not as the stereotypes I had long believed, but as thoughtful, disciplined individuals integrating it into their lives without losing control or purpose. My own experience with it was surprisingly mild and grounded, reinforcing the idea that true transformation doesn’t come from external substances but from within. This realization highlighted how our fears and rigid expectations, especially around concepts like balance, can actually limit us.

Forget everything you think you know. It’s time for a reality check.

The Problem: You’re Living in the Past

Here’s the deal: most of you are living in a state of perpetual equilibrium. You crave balance, stability, and predictability. You think that’s the goal. A life free of stress, a body in perfect homeostasis. It’s a comforting thought. It’s also complete and utter bullshit. This idea that we should be striving for a state of perfect, static balance is a dangerous myth. It's a recipe for stagnation and, ultimately, for extinction. The universe doesn't do static. It's a dynamic, ever-changing, chaotic place. And we are a part of it.

Life isn’t about balance. Life exists on the edge of chaos.

So what does that mean for you? It means that your obsession with balance is actually holding you back. You’re a Backward-Looking Person (BLP), clinging to a past that no longer exists, resisting the natural flow of the universe. You’re trying to build a dam in the middle of a river, and you’re wondering why you’re getting swept away. You're the person who keeps bringing up that one time you got hurt, that one failure that defines you. You're the person who's afraid to take risks, to try new things, because you're terrified of losing the little bit of stability you've managed to create for yourself.

Forward-Looking People (FLPs), on the other hand, understand that the only constant is change. They embrace the chaos. They lean into the discomfort. They adapt. And the endocannabinoid system is the biological mechanism that allows them to do it. They're the ones who see challenges as opportunities, who are constantly learning and growing and evolving. They're the ones who are truly alive.

The Application: Flowing Forward

So how do you apply this in your own life? How do you go from being a BLP to an FLP? It’s not about getting stoned and watching cartoons. It’s about using cannabis as a sacrament, a tool for introspection and self-discovery. It's about creating a ritual around your consumption, a space for quiet contemplation and deep listening.

Then I rediscovered cannabis. Not as a party drug, but as a medicine. I started using it in a more mindful way, with intention. I would consume a small amount and then meditate, or journal, or go for a walk in nature. And slowly, things started to shift. The first time I did this, I sat on my porch and just watched the sunset. I mean, I really watched it. I saw colors I had never seen before. I felt a sense of connection to the world around me that I hadn't felt since I was a child. It was a profound and deeply moving experience.

And you know what? It was terrifying. It was also the most liberating experience of my life. My business turned around. My relationships improved. I felt a sense of peace and purpose that I had never known before. I started to see the world not as a series of problems to be solved, but as a series of opportunities to be embraced.

This is the power of cannabis. It’s not about escaping reality. It’s about diving deeper into it. It’s about peeling back the layers of conditioning and rediscovering the person you were always meant to be. It's about remembering that you are a part of this wild, chaotic, beautiful universe, not separate from it.

The Takeaway: Your Action Items

Ready to stop fighting the current and start flowing with it? Here’s what you need to do:

  1. Educate Yourself: Stop listening to the propaganda and start learning the science. Read Dr. Bob Melamede’s work. Watch his lectures on YouTube. Understand the profound connection between far-from-equilibrium thermodynamics and the endocannabinoid system. Don't just take my word for it. Do your own research. Be skeptical. Be curious.
  2. Start Low and Go Slow: If you’re new to cannabis, don’t be a hero. Start with a low dose and see how you feel. The goal is not to get obliterated, it’s to find the minimum effective dose that allows you to tap into a state of enhanced awareness and creativity. This is a marathon, not a sprint. Be patient with yourself and with the process.
  3. Set an Intention: Before you consume, take a moment to set an intention. What do you want to achieve? What problem are you trying to solve? What aspect of yourself are you trying to understand? This simple act of mindfulness can make all the difference. Write it down. Say it out loud. Make it real.
  4. Integrate the Experience: The real work begins after the high has faded. Take time to journal, to reflect, to integrate the insights you’ve gained into your daily life. This is how you turn a fleeting experience into lasting change. Don't just have the experience; let the experience have you. Let it change you from the inside out.

This isn’t about becoming a stoner. It’s about becoming a scientist of your own life. It’s about using this powerful plant to unlock your full potential and become the adaptable, resilient, forward-looking human you were always meant to be.

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