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Episode 114 Health & Biology

Why You're Inflamed (And What To Do About It)

Chronic inflammation is behind almost every modern disease. The ECS is your body's anti-inflammatory system. Connect the dots.

By Justin Hartfield 4:20 Health & Biology Updated December 22, 2025
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Justin Hartfield

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Justin Hartfield

Founder of Weedmaps, student of Dr. Bob Melamede, and explorer of far-from-equilibrium systems. Connecting thermodynamics, consciousness, and human potential.

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Why You're Inflamed (And What To Do About It)

Let's get one thing straight: the concept of "balance" is bullshit. Your body isn't a perfectly calibrated machine, humming along in a state of delicate equilibrium. It's a chaotic, adaptive, far-from-equilibrium system, constantly battling for order in a universe that relentlessly pushes for disorder. And that nagging, persistent inflammation you feel? That's the price you pay for ignoring this fundamental truth.

You've been told to eat anti-inflammatory foods, to seek balance, to find your center. But what if I told you that inflammation is a necessary part of life? What if the real problem isn't inflammation itself, but your body's inability to control it? What if the solution isn't some mythical state of balance, but a dynamic, adaptive process of flowing forward?

This isn't some new-age wellness fad. This is hard science, rooted in the second law of thermodynamics and the groundbreaking work of Dr. Bob Melamede. It's time to unlearn everything you think you know about inflammation and discover the profound, elegant system your body already has in place to manage it: the endocannabinoid system (ECS).

The Problem: Chasing a Ghost Named 'Balance'

For decades, we've been fed a lie. The wellness industry, and even mainstream medicine, has peddled the idea that health is about achieving a state of perfect balance. We're told to balance our hormones, balance our diets, balance our lives. But this is a fundamental misunderstanding of how life actually works.

Why Youre Inflamed And What To Do About It
The ECS is your body's anti-inflammatory system

Life isn't a static state. It's a process. A verb, not a noun. As Dr. Melamede, the stoned-out hippie with a PhD, so brilliantly articulated, living systems are far-from-equilibrium structures. We are open systems, constantly exchanging energy and matter with our environment to maintain our complexity and order. We are dissipative structures, creating order by dissipating entropy (disorder) into our surroundings.

"Life is a far-from-equilibrium dissipative structure that maintains its localized, complex organization at the expense of creating entropy in its environment." - Dr. Bob Melamede

When you try to force your body into a state of static balance, you're working against the very nature of life itself. You're trying to stop the flow, to dam the river. And what happens when you dam a river? The water becomes stagnant, putrid, and diseased. The same thing happens in your body. When you disrupt the natural flow of energy and information, you create the conditions for chronic inflammation.

Chronic inflammation is the smoldering fire that underlies nearly every modern disease: heart disease, diabetes, cancer, autoimmune disorders, and even depression. It's not the acute inflammation that helps you heal from an injury. It's a low-grade, persistent inflammation that slowly but surely degrades your health.

And the root cause of this chronic inflammation? A dysfunctional endocannabinoid system.

The Application: How to flow

So, how do you cultivate a healthy, resilient endocannabinoid system? How do you become a Forward-Looking Person (FLP), embracing the arrow of time and flowing forward with the current of life?

It's not about taking a magic pill or following a rigid set of rules. It's about adopting a lifestyle that supports your body's innate intelligence. It's about creating the conditions for your ECS to thrive.

Here are a few practical ways to do just that:

  • Embrace hormesis: Hormesis is the idea that a little bit of stress is good for you. Things like exercise, intermittent fasting, and cold exposure challenge your body in a way that stimulates an adaptive response, strengthening your ECS and making you more resilient.
  • Eat a nutrient-dense, anti-inflammatory diet: This isn't about balance. It's about providing your body with the raw materials it needs to function optimally. Focus on whole, unprocessed foods, healthy fats, and a wide variety of colorful plants.
  • Prioritize sleep: Sleep is when your body does its most important repair work. It's when your brain flushes out metabolic waste and your ECS recalibrates. Make sleep a non-negotiable priority.
  • Manage stress: Chronic stress is a major disruptor of the ECS. Find healthy ways to manage stress, whether it's through meditation, yoga, spending time in nature, or connecting with loved ones.
  • Consider cannabis: For some people, particularly those with a deficient ECS, cannabis can be a powerful tool for restoring homeostasis. It's not about getting high. It's about providing your body with the cannabinoids it needs to function properly.

The Takeaway: You Are the Flow

You are not a machine. You are a dynamic, adaptive, far-from-equilibrium system. You are a process, not a thing. And the key to health and longevity is not to seek balance, but to embrace the flow.

This is a radical departure from the prevailing medical paradigm, which views the body as a collection of separate parts that can be treated in isolation. But the body is not a machine. It is a complex, interconnected system, and you cannot treat one part without affecting the whole. The reductionist approach of modern medicine has failed us, and it is time for a new paradigm, one that recognizes the holistic nature of health and the profound wisdom of the body.

This new paradigm is rooted in the principles of far-from-equilibrium thermodynamics, and it is embodied in the endocannabinoid system. The ECS is the missing link in our understanding of health and disease, and it holds the key to unlocking our full potential for healing and transformation.

So, I invite you to join me on this journey of discovery. I invite you to challenge your assumptions, to question the status quo, and to embrace a new way of thinking about your health. I invite you to become a Forward-Looking Person, to flow with the arrow of time, and to create a life of vibrant health, boundless energy, and limitless possibility.

Your body already has everything it needs to heal and thrive. It has the endocannabinoid system, a masterpiece of biological engineering that is constantly working to keep you healthy and resilient. Your job is to get out of its way.

Stop chasing the ghost of balance. Stop fighting against the current of life. Instead, learn to flow with it. Learn to embrace the chaos, to adapt to change, and to trust in your body's innate intelligence.

References

  1. Melamede, R. (2005). Harm reduction-the cannabis paradox. Harm Reduction Journal, 2(1), 1-5.
  2. Barrie, N., & Manolios, N. (2017). The endocannabinoid system in pain and inflammation: its relevance to rheumatic disease. European journal of rheumatology, 4(3), 210.
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