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The Most Important System You've Never Heard Of

Discovered in the 1990s, still not taught in most medical schools. The endocannabinoid system and why the medical establishment is 30 years behind.

By Justin Hartfield 4:20 The Endocannabinoid System Updated December 22, 2025
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Justin Hartfield

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Justin Hartfield

Founder of Weedmaps, student of Dr. Bob Melamede, and explorer of far-from-equilibrium systems. Connecting thermodynamics, consciousness, and human potential.

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Let me ask you something. What if I told you the most important system in your body, the one that regulates literally everything from your mood to your appetite to your immune system, was discovered over 30 years ago, yet your doctor probably knows jack-shit about it? You’d call me crazy, right? Or a conspiracy theorist. Well, get ready to call me crazy.

Because that’s exactly what I’m telling you. The endocannabinoid system, or ECS, is the most important physiological system in the human body, and it’s been systematically ignored by the medical establishment for three decades. This isn’t a conspiracy theory. It’s a fact. And it’s a damn shame.

The Problem: A 30-Year Lag in Medical Education

You go to your doctor, you trust them with your health, with your life. You assume they’re up-to-date on the latest medical science. But what if they’re not? What if their knowledge is based on a curriculum that’s 30 years out of date? That’s the reality for most medical professionals when it comes to the endocannabinoid system.

Discovered in the early 1990s, the ECS is a master regulatory system that controls virtually all of our physiological processes. And yet, it’s still not taught in most medical schools. Think about that for a second. The system that keeps you in balance, that keeps you healthy, is a complete mystery to the people you entrust with your health. It’s like a mechanic who’s never heard of an engine. It’s malpractice on a massive scale.

Why the ignorance? It’s a combination of factors. The discovery of the ECS was inextricably linked to cannabis research, and the stigma around cannabis has created a political and cultural barrier to its acceptance. The pharmaceutical industry also has a vested interest in maintaining the status quo. Why promote a system that encourages the body to heal itself when you can sell a pill for every ill? It’s a classic case of Backward-Looking People (BLPs) resisting progress.

Let’s be clear, this isn’t a simple oversight. It’s a systemic failure. The Flexner Report of 1910, which standardized medical education in the United States, created a system that is incredibly resistant to change. It’s a system that is heavily influenced by pharmaceutical companies, who have a vested interest in promoting their own products. The ECS, which is a system that can be modulated by lifestyle changes and natural substances, is a direct threat to their business model. So they’ve done everything they can to keep it out of the curriculum.

The Application: Taking Control of Your Biology

So what does this all mean for you, in your day-to-day life? It means that you have more control over your health than you’ve been led to believe. You’re not a victim of your genes or your circumstances. You’re a dynamic, self-organizing system with the power to heal yourself.

When your ECS is functioning optimally, you’re more resilient to stress, you have a healthier appetite, you sleep better, and your mood is more stable. When it’s out of whack, you’re more susceptible to a whole host of problems, from anxiety and depression to chronic pain and autoimmune diseases.

The good news is that there are things you can do to support your ECS. Diet, exercise, and stress management all play a role. And yes, cannabis can also be a powerful tool for modulating the ECS. But it’s not about getting high. It’s about using the plant intelligently, as a supplement to support your body’s own innate healing wisdom.

I've found this NLP trick to be particularly effective at letting go of negative energy. Visualize your feelings in all of their intensity as an orb of red energy building in your hands. Fans of Street Fighter: form a hadouken in your hands. Hold this glowing red fireball of emotion and feel its weight and heat. Feel it expanding as you pour your negative thoughts and emotions into it. Now imagine throwing your sphere of emotional baggage into a volcano, in a fire, or at an opponent (or Blanka!). Feel the burden of that emotional waste being lifted from your shoulders, into your palms, and finally out through your finger tips. As the red ball of energy leaves your hands, in its wake it leaves life-giving blue oxygen vapor. Breathe in the soothing blue air and relax your mind as you say to yourself, "Everything works out perfectly."

One evening, after practicing this visualization technique, I found myself reflecting deeply on my own life. I realized that despite my efforts to manage my emotions, I was still struggling with feelings of isolation and uncertainty about my future. This moment of honest self-reflection made me acknowledge that change was necessary and that seeking new perspectives could be the key to growth. It was this openness that eventually led me to meet a group of people who challenged my previous assumptions and introduced me to new ways of thinking.

That moment of clarity sparked a broader reevaluation of my assumptions—not just about my habits, but about how I engaged with the world around me. For example, I had long been wary of substances like cannabis, influenced by stereotypes and fear rather than understanding. But when I eventually found myself in the company of thoughtful, accomplished individuals who used it responsibly, I realized that many of my beliefs were misplaced. This experience underscored an important lesson: true well-being comes from questioning our preconceptions and actively choosing how we engage with our lives. With that mindset, I began to see the value in taking control of my own health—becoming not just a passive observer, but an active participant in my personal wellness journey.

The Takeaway: Become a Forward-Looking Person

It’s time to stop being a passive consumer of healthcare and start being an active participant in your own well-being. It’s time to become a Forward-Looking Person. Here’s how you can start:

  1. Educate yourself: Read everything you can about the endocannabinoid system. Watch Dr. Bob’s lectures on YouTube. The information is out there, you just have to look for it. A great place to start is the International Cannabinoid Research Society (ICRS) website.
  2. Question your doctor: The next time you go to your doctor, ask them about the endocannabinoid system. If they don’t know what you’re talking about, it might be time to find a new doctor. Look for a physician who practices functional or integrative medicine, as they are more likely to be knowledgeable about the ECS.
  3. Take responsibility for your health: Don’t wait for someone else to fix you. You are the only one who can do that. Start by making small changes to your diet, your exercise routine, and your mindset. Track your progress in a journal. Notice how different foods, activities, and thoughts make you feel. Become the scientist of your own life.
  4. Embrace a far-from-equilibrium lifestyle: Don’t be afraid of change. Don’t be afraid of a little chaos. It’s at the edge of chaos that we are most alive. So go ahead, take a risk, try something new, and see what happens. Learn a new skill, travel to a new place, have a conversation with someone you disagree with. The more you step outside of your comfort zone, the more you will grow.

This isn’t about rejecting modern medicine. It’s about integrating it with a more holistic understanding of the human body. It’s about recognizing that we are more than just a collection of parts. We are complex, dynamic systems with an incredible capacity for self-healing.

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