The endocannabinoid system (ECS) is the most important physiological system you've never heard of. Discovered only in the 1990s, the ECS regulates virtually every aspect of human health—from mood and appetite to immune function and cellular repair. These articles explore this remarkable system and its implications for medicine and human potential.
Dr. Bob Melamede was one of the first scientists to understand the ECS in thermodynamic terms. He saw that endocannabinoids function as the body's primary homeostatic regulators—molecules that help maintain the far-from-equilibrium state that defines life. When the ECS is functioning well, we adapt and thrive. When it's disrupted, disease follows.
These articles cover the science of the ECS: how it works, what disrupts it, and how to support it. We explore the roles of anandamide and 2-AG, the CB1 and CB2 receptors, and the enzymes that regulate cannabinoid signaling. We examine how diet, exercise, stress, and yes, cannabis affect ECS function.
Understanding the endocannabinoid system is essential for anyone interested in health optimization, cannabis medicine, or the biology of adaptation. These articles provide the foundation you need.
The System Inside You That Nobody Told You About
The endocannabinoid system is the most important regulatory system in your body. It controls mood, inflammation, appetite, memory. Why don't you know about it?
The Wizard Behind the Curtain
Dr. Bob's most powerful metaphor. Your ECS is running the show—homeostasis, healing, adaptation. Time to meet the wizard.
Why You're Probably Deficient (And Don't Know It)
Clinical Endocannabinoid Deficiency is real. Migraines, fibromyalgia, IBS—all potentially linked to an ECS that's not getting what it needs.
Your Body's Operating System
If your body were a computer, the ECS would be the operating system. It's managing everything in the background. Here's how it works.
The Lock and Key You Already Have
Cannabis doesn't get you high—it fits into receptors you already have. Your body was designed for this. The science of why prohibition makes no sense.
Homeostasis: The Word That Changes Everything
Your body is constantly trying to maintain balance. The ECS is how it does it. Understanding homeostasis is understanding health itself.
The Most Important System You've Never Heard Of
Discovered in the 1990s, still not taught in most medical schools. The endocannabinoid system and why the medical establishment is 30 years behind.
Why Cannabis Works (The Real Science)
Not stoner science. Real science. Peer-reviewed, Nobel Prize-adjacent science. How cannabinoids interface with your biology to create real effects.