Chapter 13 · 1 min
Epilogue
Back where we started
▶ Play this chapter ▶ Play this chapter Play the film from the start Opens the film at this chapter. Mouse, touch or keyboard; about 1 minutes.
The script
Every line as it is spoken in the film, in order.
Back where we started. People have burned this plant for 2,500 years, chasing a feeling.
The whole time, the lock was already in them. Their own keys were turning it, a little at a time, only where it was needed, only for moments. THC turns it everywhere, for hours.
Justin, on camera
The plant didn't build that lock. It just found it. You've been high your whole life. Now you know. Tell someone.
Sources
Every claim in this chapter with its grade: E established · M emerging (one or two studies, or animals only) · F framework.
- ERen M et al. The origins of cannabis smoking: chemical residue evidence from the first millennium BCE in the Pamirs. Sci Adv 2019;5:eaaw1391. (cannabis with high THC burned in braziers at Jirzankal Cemetery, about 500 BCE) link
- EWilson RI, Nicoll RA. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 2001;410:588–92. link
- EKreitzer AC, Regehr WG. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 2001;29:717–27. link